Tīmeklisdemonstrated that Qki-Srebp2-controlled cholesterol biosynthesis is indispensable for myelinogenesis and highlights a novel function of Qki as a transcriptional co-activator beyond its canonical function as an RNA-binding protein. Introduction The brain is the most cholesterol-rich organ, accounting for 23% of the total cholesterol in the body ... TīmeklisRegjistrimi bëhet duke shtypur në linkun Regjistrohu dhe duke plotësuar të dhënat e kërkuara. Pas plotësimit të të dhënave, ju dërgohet një email për konfirmimin e …

Jiangong Ren PubFacts

TīmeklisMechanistically, Qki-5 functions as a co-activator of Srebp2 to control transcription of the genes involved in cholesterol biosynthesis in oligodendrocytes. Consequently, Qki depletion led to substantially reduced concentration of cholesterol in mouse brain, impairing proper myelin assembly. Our study demonstrated that Qki-Srebp2 … Tīmeklis2024. gada 5. janv. · Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. QUAKING Regulates Microexon Alternative Splicing of the … kfrog concerts

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Tīmeklis2024. gada 21. maijs · Interaction between QKI-5 and mature SREBP2 was reduced in sterol-repleted cells in IPs with both anti–Qki-5 and anti-Srebp2 antibodies (Supplementary Fig. 4h, i), which suggests that interaction of QKI-5 with mature SREBP2 can be induced by a sterol-low condition to meet the high demand of … TīmeklisThe dynamics of droplet impact and splash is important in many applications, yet its analysis involves difficult intertwined aspects. Here Liu et al. make shape parametrically accessible to ... TīmeklisTogether, we propose that Qki-Srebp2–mediated cholesterol biosynthesis is essential for maintaining high demand for cholesterol in lens cells and oligodendrocytes. Our finding potentially provides tissue-specific mechanisms to modulate cholesterol biosynthesis to prevent cataracts and various neurological diseases. Keywords. isle of wight crossing times