WebJan 1, 2003 · Idiopathic polymyositis (PM) is an inflammatory myopathy characterized by the subacute onset of proximal muscle weakness. By definition, patients have no other predisposing factors, such as a family history of neuromuscular disease, endocrinopathy, exposure to myotoxic drugs or toxins, or biochemical muscle disease [].Chronic … Webhematopoetic stem cell transplant
Relapsing polymyositis in chronic graft versus host disease
WebOct 15, 2024 · Polymyositis (PM) is a rare neuromuscular phenotype of cGVHD. It mainly manifests as symmetrical proximal weakness of the muscles with or without myalgia, elevated serum creatine kinase (CK), or myogenic damage (visible under electromyography). WebOct 15, 2002 · GVHD remains a major complication of allogeneic blood and marrow transplantation. 1, 2, 3 T cells are key mediators of GVHD, as shown in both animal … global reentry tsa login
Polymyositis as a manifestation of chronic graft‐versus‐host …
WebJan 22, 2015 · Chronic graft-versus-host disease (GVHD) remains a common and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2-year cumulative incidence of chronic GVHD requiring systemic treatment is ∼30% to 40% by National Institutes of Health criteria. WebMyositis associated with graft-versus-host-disease (GVHD) typically presents with proximal muscle weakness, myalgias, and a raised creatinine phosphokinase (CPK) level. We report a case of a 51 year old man who developed respiratory muscle weakness five years after an allogeneic bone marrow transplant for multiple myeloma. WebJan 13, 2010 · The symptoms of chronic GVHD-related polymyositis are indistinguishable from those of idiopathic polymyositis. The context of transplantation and a decrease or interruption of prophylaxis suggest the diagnosis of GVHD-related polymyositis, especially if other manifestations of GVHD are associated. global referral blue care network