WebIn vivo, this may lead to poorer initial control of viral infection, facilitating CHIKV replication and dissemination to other sites such as joints. This may explain the consistent past findings that the ECSA genotype is associated with greater viremia and severity of symptoms than the Asian genotype. Knowledge of CHIKV genotype-specific ... WebApr 23, 2016 · These mutations have differential effects on genomic and subgenomic alphavirus RNA production, suggesting that the cytopathicity induced by alphavirus replication, although clearly linked, does not solely depend on transcriptional shut-off but—at least in the case of CHIKV—requires heavily reduced viral replication as well . …
Suramin Inhibits Chikungunya Virus Replication by …
WebChikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause a debilitating disease that is primarily characterized by persistent joint pain. CHIKV has … WebMar 24, 2024 · As for CHIKV replication, siRNA-mediated depletion of 13 ESCRT genes markedly reduced the level of virus replication in HEK293T cells. Interestingly, some of the ESCRT factors were found to be required for CHIKV RNA synthesis and the post-translation step, which was presumably at the extracellular release step of the virion, as reported in … gregor hembrough
Genome-Wide Approaches to Unravel the Host Factors Involved in ...
WebMar 1, 2024 · Although some additional proviral host factors have been identified (70, 74, 78, 98 – 100), specific host pathways and mechanisms that promote replication of CHIKV are areas of active research. A comprehensive understanding of the CHIKV replication cycle in both mammalian and mosquito cells is essential for development of effective … WebMar 24, 2014 · Chikungunya is an acute illness that is characterized by fever, rash and arthralgia. The chikungunya virus (CHIKV) that causes this disease is an alphavirus that belongs to the Togaviridae family [], transmitted by different mosquito species, including the Asian tiger mosquito (Aedes albopictus, Culicidae), one of the most invasive in the … WebAug 11, 2024 · As predicted for a positive role of KIAA1456 in CHIKV infection, overexpression of KIAA1456 protein favored CHIKV RNA replication (fold change 1.2, p-value = 0.0045, two-tailed t-test) (Fig. 5d ... gregor heating vacancies